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Laboratorio di ricerca

Lab. nameBioPaCT - Biology and Pathology of soft Connective Tissues 
Principal Investigator Daniela Quaglino 
ComponentsDaniela Quaglino  (Principal Investigator )
Sabatino Pacia  (Dottorando )
Federica Boraldi  (Ricercatore )
DescriptionThe biology and pathology of the extracellular matrix is investigated looking at 1) structural and metabolic alterations occurring in skin and in blood vessels during aging, in acquired and in genetic diseases, 2) DNA sequencing and molecular pathways leading to ectopic calcifications (ie. PXE and PXE-like disorders), 3) protein profiling of human fibroblasts in different experimental conditions, 4) structural and biological characterization of elastin and elastin-derived peptides.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsExtracellular matrix, aging, ectopic calcification, connective tissue genetic diseases, elastin  
ERC Sectors LS4_1 Organ physiology and pathophysiology LS4_1 Organ physiology and pathophysiology LS4_4 Ageing LS4_5 Metabolism, biological basis of metabolism related disorders LS4_5 Metabolism, biological basis of metabolism related disorders LS4_5 Metabolism, biological basis of metabolism related disorders  
InstrumentationTermal cycler BIOMETRA, -80C Freezers , IpgPhor IEF and Ettan Dalt 6 for 2D-IPG, Image Scanner II, Typhoon 9400 and related softwares), Zeiss Axiophot light and fluorescence microscope, 1microtome and 2 ultramicrotomes, 2 centrifuges, 2 chemical hoods 
Research Lines Translational Medicine

Methodologies Structural and ultrastructural analyses by light and fluorescence microscopy, confocal microscopy, transmission and scanning electron microscopy; immunocytochemistry and immunoelectronmicroscopy; protein and proteome analysis associated with MS/MS; PCR and DNA sequencing, cell culture, biocompatibility tests.