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Laboratorio di ricerca

Lab. nameChemistry Solid State Charaterization Lab 
Principal Investigator Maria Cristina Gamberini 
ComponentsMaria Cristina Gamberini  (Principal Investigator )
DescriptionTopics covered: a) crystallization and characterization (theoretical and applied aspects) of active pharmaceutical ingredients (APIs), for the detection of different polymorphic forms related to pharmaceutical formulations. APIs qualitative and quantitative analyzes are conducted on pure substance and on finished pharmaceutical product (solid state or in solution), with attention to possible changes induced by industrial processes (grinding, heating, compression) or from storage; b) cosmetic and pharmaceutical ancient residues characterization and validation of the analytical data obtained by analysis of raw materials and formulations reference reproduced in the laboratory, both subjected to different methods of artificial aging; c) application and development of the methodology SERS (surface-enhanced Raman scattering) for the determination of APIs or cosmetic ingredients in complex matrices d) analysis of biological matrices with separation techniques LC-MS/MS/MS.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsSpectroscopy, Raman, SERS, Pharmaceutical Polymorphs, LC-MS/MS/MS 
ERC Sectors 
InstrumentationDSC, HPLC, Kofler; Rotavapor, Centrifuge, Heating-stirring module, ultrasonic bath, stove, pH meter, 2 hot plates, vacuum pump, Dubnoff bath 
Research Lines Drug discovery, analysis, delivery and molecular engineering platforms

Methodologies Gas chromatographic techniques and liquid chromatography coupled to mass spectrometry (GC-MS, LC-MS/MS/MS), spectroscopic techniques (ATR / FT-IR, FT-IR, Raman microscopy, FT-Raman, SERS method), X-ray powder diffractometry (XRPD) and single crystal, differential thermal analysis (DTA), thermogravimetric (TGA) and differential calorimetry (DSC)