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Laboratorio di ricerca

Lab. nameCMR Gene Therapy Laboratory 
Principal Investigator Michele De Luca 
ComponentsMichele De Luca  (Principal Investigator )
DescriptionMichele De Luca is the coordinator of GENE THERAPY Program. His main research activity is focused on definition of experimental and clinical protocols for gene therapy of genetic diseases of the skin (such as different forms of Epidermolysis Bullosa) and ocular epithelia (such as different forms of corneal distophy) by ex-vivo correction of epithelial stem cells. He is also invovled in BASIC RESEARCH activity: culture and functional characterization of epithelial stem cells (epidermis, cornea, conjunctiva, urethra and oral mucosa) and studies of molecular mechanisms regulating self-renewal, proliferation and differentiation of squamous epithelial stem cells by conventional methods integrated with genomic, epigenomic and transcriptomic technologies;
 He collaborates with the CELL THERAPY Coordinator, Graziella Pellegrini, in definition of experimental and clinical protocols aimed at clinical application of epidermal stem cells in different cutaneous pathologies, and stem cells of conjunctival, urethral and buccal epithelia in traumatic destruction of the conjunctival epithelium, dry-eye Syndrome, posterior hypospadias, recurring urethral stenosis, reconstructive surgery of blindness due to bilateral ocular surface damage.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
Keywordsregenerative medicine, epithelial stem cell, cell therapy, gene therapy, epidermolysis bullosa 
ERC Sectors 
Instrumentation5 fully equipped BL2 cell culture rooms, confocal microscope, time-laps microscope, X-ray cell irradiatior, cytofluorimeter, real-time PCR, laser microdissector, microtome.  
Research Lines Evolutionary, environmental and translational biology

Multi-scale and cell-based approaches to genetic and chronic disorders and development of advanced therapies

Methodologies Cell cultures, gene correction, gene expression analysis, characterization of stem cell-related genes, cell imaging, tissue engineering 
Web Site www.cmr.unimore.it/en