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Laboratorio di ricerca

Lab. nameGene expression  
Principal Investigator Vincenzo Zappavigna 
ComponentsVincenzo Zappavigna  (Principal Investigator )
DescriptionMy lab has since long been interested in the transcriptional control of developmental processes, especially those regulated by Hox genes and their co-factors. In the past years our main focus has shifted on the involvement of Hox transcription factors in cell cycle control and tumorigenesis, and on post-transcriptional regulatory mechanisms. The two main research topics we are currently exploring are: Study of the mechanisms underlying the perturbation of cell cycle control by NUP98-HOX and other NUP98 fusion oncoproteins; Study of the transcriptional regulation of miR196b and of the CDX2-miR196b-GATA6 regulatory network in colon carcinoma. 
Addressvia Giuseppe Campi, 287 - 41125 Modena 
Keywordsdevelopmental biology, gene expression, Hox genes, transcription factors, cancer biology 
ERC Sectors 
InstrumentationRT-PCR, Centrifuges, -80C, incubator 
Research Lines Translational Medicine

Methodologies Chromatin immunoprecipitation, retroviral vector gene delivery, cell culture, Recombinant DNA technologies, Recombinant protein production 
Web Site www.mrm.unimore.it/site/home/research/topics.html