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Laboratorio di ricerca

Lab. nameMolecular neuropsychopharmacology 
Principal Investigator Nicoletta Brunello 
ComponentsNicoletta Brunello  (Principal Investigator )
DescriptionStudy of the molecular targets involved in the mechanism of action of antidepressant and antipsychotic drugs Characterization of animal models of mental disorders and response to psychotropic drugs Investigation of the role of centrally expressed cytokines on long-term impairment of hippocampal plasticity and related behaviors. Acute and chronic effects of environmental stress on gene expression in animal models of depression Interaction of inflammatory biomarkers and neurotrophins in the CNS in relation to psychotropic drug treatment and response  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
Keywordspsychopharmacology, pharmacogenomic, animal models, neurobiology, neuroimmunopharmacology 
ERC Sectors 
InstrumentationBench centrifuges (1.8 ml tubes), Centrifuge, Dry bath, Hybridization oven, Microbiological Incubator, Microplate shaker, Microwave oven, Mini centrifuge, Orbital shaker, PCR, Power supply, UV/visible spectrophotomer, Vacuum Pump, Vortex 
Research Lines Multi-scale and cell-based approaches to genetic and chronic disorders and development of advanced therapies

Methodologies Behavioural test and animal handling Cell culture and in vitro analysis of proliferation, viability, cell death Preparation and analysis of DNA and RNA; RT-PCR, PCR and Real Time PCR, DNA cloning, RNase Protection Assay, in situ hybridization 3'-RACE e 5'-RACE; Protein analysis: Western Blotting, EMSA, ELISA, EIA, immunocitochemistry