Ti trovi qui: Home » Ricerca » Laboratorio di ricerca

Laboratorio di ricerca

Lab. namePharmacology and Toxicology 
Principal Investigator Lorenzo Corsi 
ComponentsLorenzo Corsi  (Principal Investigator )
Descriptiona) Study of new AMPA antagonist receptor as potential anticancer This research aims to evaluate the anti-tumor potential of new antagonists of AMPA glutamate receptor subtype and possibly identifying the molecular determinants acting on cytoskeleton organisation and cell division. b) Study of biochemical pathways involved in degenerative processes: new targets for anti-cancer compounds and/or preventing neurodegeneration: The purpose of this research is devoted to the study of new pathways involved in the process of degeneration (ie TSPO recepor complex) as a possible pharmacological target in cancer treatment or neurodegenerative disorders. c) Nanotoxicology: Evaluation of the potential carcinogenic and autoimmune activity of metal nanoparticles: in vitro studies. d) Toxicological evaluation of food supplements. a)Evaluation of the biomechanical and cytokinesis modulation of tumoral cells by new drugs. b) Study of biochemical pathways involved in degenerative processes: new targets for anti-cancer compounds and/or preventing neurodegeneration: The purpose of this research is devoted to the study of new pathways involved in the process of degeneration (ie TSPO recepor complex) as a possible pharmacological target in cancer treatment or neurodegenerative disorders. c) Nanotoxicology: Evaluation of the potential carcinogenic and autoimmune activity of metal nanoparticles: in vitro studies. d) Toxicological evaluation of food supplements.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsCancer, Nanoparticles, apoptosis, Cytotoxicity 
ERC Sectors LS4_6 Cancer and its biological basis LS5_2 Molecular and cellular neuroscience LS7_3 Pharmacology, pharmacogenomics, drug discovery and design, drug therapy LS7_5 Toxicology  
InstrumentationElisa spettrofotometer; Fluorometer; AFM 
Research Lines Drug discovery, analysis, delivery and molecular engineering platforms

Evolutionary, environmental and translational biology

Multi-scale and cell-based approaches to genetic and chronic disorders and development of advanced therapies

Plant, animal and microbial research for functional and sustainable food

Methodologies Cell culture; molecular biology; (immunblotting; immunofluerscence, siRNA ecc); in vitro cell biology assay (apoptosis, BrdU, ,ROS, two stage trnasf. assay ecc)