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Gruppo di ricerca

Lab. nameBioinorganic Chemistry and Bioelectrochemistry Lab 
Principal Investigator Marco Sola 
ComponentsMarco Sola  (Principal Investigator )
Antonio Ranieri   (Ricercatore )
Giulia Di Rocco   (Ricercatore )
DescriptionThe main research interest in our laboratories is the investigation of metal-containing, electron transfer (ET) proteins and enzymes of biomedical interest and for bioremediation. The aim is twofold: from a fundamental point of view, we are interested in unveiling how the protein structure, dynamics and environmental conditions affect the ET and, eventually the catalytic functionality. In parallel, our investigation is devoted to the design of bio(in)organic interfaces, based on the adsorption of metalloproteins on bare or modified metal electrodes, for biosensing and biocatalysis. This approach makes the application of electrochemical and spectroscopic methods also a very attractive strategy for the construction of reagent-less platforms for high-throughput screening of new drug candidates. Recently we focused on the production and characterization of enzymes acting on recalcitrant polymers such as cellulose, chitin, polyethylene terephthalate and polystyrene for the recycling of polluting waste material. Moreover, our recent research interests include the investigation of the effect of pathogenic mutations or of the presence of exogenous molecules on the structure, dynamics, and functionality of metalloproteins, with the aim of unraveling the molecular effectors that underlie the onset of a disease.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsMetalloproteins, Electrochemistry, Nanobiotechnology, Surface Scienc, Sensing 
ERC Sectors LS1_2 Biochemistry LS1_7 Molecular biophysics, biomechanics, bioenergetics LS1_11 Chemical biology LS2_8 Proteomics LS9_7 Environmental biotechnology and bioengineering PE4_2 Spectroscopic and spectrometric techniques PE4_8 Electrochemistry, electrodialysis, microfluidics, sensors PE4_11 Physical chemistry of biological systems  
InstrumentationPotentiostat/Galvanostats and UV-vis spectrophotometer, Orbital Shaker, Incubator, Refrigerators, Thermocycler FPLC (Fast pressure Liquid Chromatography), Microcentrifuge, Ultracentrifuge. 
Research Lines Agrifood and Environment

Translational Medicine

Methodologies Surface chemistry, UV-vis spectroscopy, MCD, Resonance Raman and SERRS spectroscopies, Fluorescence spectroscopy, Mass Spectrometry, Electrochemistry, cloning, expression, purification of recombinant proteins in E.coli and microalgae.