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Gruppo di ricerca

Lab. namePharmacology and Toxicology 
Principal Investigator Lorenzo Corsi 
ComponentsLorenzo Corsi  (Principal Investigator )
Clarissa Caroli  (Dottorando )
Vincenzo Zappavigna  (Collaboratore )
Federica Pellati  (Collaboratore )
Descriptiona) Study of new drugs and/or phtycomplexes acting as as potential anticancer This research aims to evaluate the anti-tumor potential of new compounds by identifying the molecular determinants acting on cytoskeleton organisation and cell division. b) Study of biochemical pathways involved in degenerative processes: new targets for anti-cancer compounds and/or preventing neurodegeneration: The purpose of this research is devoted to the study of new pathways involved in the process of degeneration (ie TSPO recepor complex; KIF 11, Rho A; etc) as a possible pharmacological target in cancer treatment or neurodegenerative disorders. c) Nanotoxicology: Evaluation of the potential carcinogenic and autoimmune activity of metal nanoparticles: in vitro studies. d) Toxicological evaluation of food supplements.  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsCancer, Nanoparticles, apoptosis, Cytotoxicity 
ERC Sectors LS1_7 Molecular biophysics, biomechanics, bioenergetics LS3_1 Cell cycle, cell division and growth LS3_3 Cell behaviour, including control of cell shape, cell migration LS4_12 Cancer LS5_1 Neuronal cells LS7_7 Pharmacology and toxicology  
InstrumentationElisa spettrofotometer; Fluorometer; AFM 
Research Lines Translational Medicine

Methodologies Cell culture; molecular biology; (immunblotting; immunofluerscence, siRNA ecc); in vitro cell biology assay (apoptosis, BrdU, ,ROS, two stage trnasf. assay ecc)