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Laboratorio di ricerca

Lab. nameCellular and molecular Immunology 
Principal Investigator Marcello Pinti 
ComponentsMarcello Pinti  (Principal Investigator )
Sara De Biasi  (Assegnista )
Anna De Gaetano  (Assegnista )
DescriptionThe research activity of the Lab is focused on three main topics: 1. Role of circulating mitochondrial DNA (mtDNA) as a proinflammatory molecule. mtDNA, when released outside the cells, can act as a damage associated molecular pattern, and triggers an inflammatory reaction. We analyse the role of mtDNA in the pathogenesis of chronic inflammatory diseases, and in physiological aging. 2. Analysis of mitochondrial functionality in peripheral blood lymphocytes from patients with multiple sclerosis (MS). MS is an autoimmune disease in which a specific immune response versus the myelin basic protein is present. As activation of T cells is characterized by a deep change in mitochondrial metabolism, our aim is to understand if different forms of MS are characterized by different mitochondrial activity. 3. Comprehension of mitochondrial proteases regulation in colorectal cancer pathogenesis. 
Addressvia Giuseppe Campi, 287 - 41125 Modena 
Keywordsmitochondria, mtDNA, Lon protease, inflammation, multiple sclerosis,  
ERC Sectors LS3_6 Organelle biology LS4_4 Ageing LS4_6 Cancer and its biological basis LS6_1 Innate immunity and inflammation LS6_2 Adaptive immunity  
InstrumentationBiorad S3 Cell Sorter, Attune NxT Flow Cytometer, Biorad CFX 96 Real time PCR 
Research Lines Translational Medicine

Methodologies Multicolour flow cytometry; qPCR; cell sorting;