Laboratorio di ricerca
| Lab. name | Gene expression |
|---|---|
| Principal Investigator | Vincenzo Zappavigna |
| Components | Vincenzo Zappavigna (Principal Investigator
)
|
| Description | My lab has since long been interested in the transcriptional control of developmental processes, especially those regulated by Hox genes and their co-factors. In the past years our main focus has shifted on the involvement of Hox transcription factors in cell cycle control and tumorigenesis, and on post-transcriptional regulatory mechanisms. The two main research topics we are currently exploring are: Study of the mechanisms underlying the perturbation of cell cycle control by NUP98-HOX and other NUP98 fusion oncoproteins; Study of the transcriptional regulation of miR196b and of the CDX2-miR196b-GATA6 regulatory network in colon carcinoma. |
| Address | via Giuseppe Campi, 287 - 41125 Modena |
| Keywords | developmental biology, gene expression, Hox genes, transcription factors, cancer biology |
| ERC Sectors | |
| Instrumentation | RT-PCR, Centrifuges, -80C, incubator |
| Research Lines | Translational Medicine |
| Methodologies | Chromatin immunoprecipitation, retroviral vector gene delivery, cell culture, Recombinant DNA technologies, Recombinant protein production |
| Web Site | www.mrm.unimore.it/site/home/research/topics.html |