Laboratorio di ricerca
| Lab. name | Molecular neuropsychopharmacology |
|---|---|
| Principal Investigator | Nicoletta Brunello |
| Components | Nicoletta Brunello (Principal Investigator
)
|
| Description | Study of the molecular targets involved in the mechanism of action of antidepressant and antipsychotic drugs Characterization of animal models of mental disorders and response to psychotropic drugs Investigation of the role of centrally expressed cytokines on long-term impairment of hippocampal plasticity and related behaviors. Acute and chronic effects of environmental stress on gene expression in animal models of depression Interaction of inflammatory biomarkers and neurotrophins in the CNS in relation to psychotropic drug treatment and response |
| Address | via Giuseppe Campi, 287 - 41125 Modena |
| Keywords | psychopharmacology, pharmacogenomic, animal models, neurobiology, neuroimmunopharmacology |
| ERC Sectors | |
| Instrumentation | Bench centrifuges (1.8 ml tubes), Centrifuge, Dry bath, Hybridization oven, Microbiological Incubator, Microplate shaker, Microwave oven, Mini centrifuge, Orbital shaker, PCR, Power supply, UV/visible spectrophotomer, Vacuum Pump, Vortex |
| Research Lines | Translational Medicine |
| Methodologies | Behavioural test and animal handling Cell culture and in vitro analysis of proliferation, viability, cell death Preparation and analysis of DNA and RNA; RT-PCR, PCR and Real Time PCR, DNA cloning, RNase Protection Assay, in situ hybridization 3'-RACE e 5'-RACE; Protein analysis: Western Blotting, EMSA, ELISA, EIA, immunocitochemistry |