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Laboratorio di ricerca

Lab. nameNutritional Biochemistry 
Principal Investigator Angela Conte 
ComponentsAngela Conte  (Principal Investigator )
Davide Tagliazucchi  (Collaboratore )
DescriptionResearch activities in the Nutritional Biochemistry lab: • Determination of peptide profiles during physiological digestion of milk and vegetable proteins. Fractionation, identification and characterization of antihypertensive, antioxidant and anti-cancer peptides in protein digests. • Determination and characterization of cell-envelope proteases of Lactobacillus casei and Lactobacillus rhamnosus (in collaboration with the Food Microbiology lab) • Evaluation of cytotoxic and anti-proliferative activity of polyphenols metabolites and other food bioactive compounds against colonic adenocarcinoma cell lines. • Identification of new natural compounds with specific biological activity concerning the modulation of digestive enzyme, the protection against oxidative stress and protein glycation. 
Addressvia Giuseppe Campi, 287 - 41125 Modena 
Keywordspolyphenols, peptidomic, mass spectrometry, colon cancer, bioactivity 
ERC Sectors 
InstrumentationCell culture facilities, spectrofluorimeter, spectrophotometer, electrophoresis and western blot facilities, microplate reader 
Research Lines Agrifood and Environment

Methodologies Cell culture techniques (colon cancer cell lines), mass spectrometry, peptidomics, enzymology, protein/peptide purification, western blot, simulated digestion protocols, polyphenol determination in food.