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Laboratorio di ricerca

Lab. nameOrganic synthesis lab 
Principal Investigator Fabio Prati 
ComponentsFabio Prati  (Principal Investigator )
Francesco Fini  (Ricercatore )
Emilia Caselli  (Ricercatore )
DescriptionThe group focuses on synthesis and synthetic methodology to tackle problems of relevance to medicinal chemistry and biotechnology. In particular the group is developing new application of boronic acids as useful tools in organic synthesis Essentially, the three current active projects are: 1. rational design and enantioselective syntheses of boronic acids as potent beta-lactamases inhibitors, capable of restoring in vivo efficient antibacterial activity of beta-lactam antibiotics in clinically resistant strains; 2. syntheses of (di)peptide mimics by mean of click-chemistry to discover new application of borono-aminoacids in proteases inhibition; 3. total synthesis of natural products such as ferormones and plants or fungi metabolites by organometallic catalysis  
Addressvia Giuseppe Campi, 287 - 41125 Modena 
KeywordsAsymmetric synthesis. Enzyme inhibitions. Boronic acids. Total synthesis. Peptidomimetics.  
ERC Sectors LS7_3 Pharmacology, pharmacogenomics, drug discovery and design, drug therapy PE5_17 Organic chemistry  
InstrumentationPolarimeter - 2 Gaschromatographs - 1 HPLC 
Research Lines Translational Medicine

Methodologies Sintesi stereoselettive - Organocatalisi - Catalisi organometallica